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纳米化头孢唑林钠对细菌敏感性的体外实验

Sensitivity of nanoparticlized cefazolin sodium to the bacteria in vitro
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摘要 目的:探讨头孢唑林钠纳米化后体外细菌对其敏感性是否改变。方法:采用微量稀释法测定头孢唑林钠纳米化前后对金葡菌和大肠杆菌的最低抑菌浓度。结果:纳米化头孢唑林钠对金葡菌和大肠杆菌的最低抑菌浓度,与未纳米化头孢唑林钠相比,没有明显差别;且纳米化后的头孢唑林钠的抑菌能力有增强的趋势。结论:纳米化头孢唑林钠不影响其对细菌的敏感性。 Objective To investigate whether the in vitro sensitivity of cefazolin sodium to the bacteria was altered after nanoparticlization. Methods The minimal inhibitory concentrations(MIC) of cefazolin sodium before and after nanoparticlization to S.aureaus and E.coli. were determined by microdilution. Results The MIC of nanoparticlized cefazolin sodium to S.aureaus and E.coli. had no significant change compared with that of non-nanoparticlized one. Conclusion Nanoparticlization will not decrease the sensitivity of cefazolin sodium to the bacteria.
出处 《中南大学学报(医学版)》 CAS CSCD 北大核心 2005年第3期318-320,共3页 Journal of Central South University :Medical Science
基金 国家"863"子项目(2001AA218011) 湖南省教育厅科研基金(湘教通[2001]207)
关键词 头孢唑林钠 纳米粒 最低抑菌浓度 cefazolin sodium nanoparticlization MIC
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