摘要
对１６３例丙型肝炎定期随访８年，发现ＡＬＴ异常率在病后１年内，病后１、２、５石年和８年分别为１００％、７３％、５７％、３７％和２８％，表现为持续性和波动性异常，后者约占１／３～１／２。抗－ＨＣＶ阳性率在病后两月内、２～６月和６～１２月及１、２、５年和８年分别为５６％、９３％、９４％、９６％、９７％、９３％和８３％。抗－ＨＣＶ阳转阴仅见于ＡＬＴ复常者，病后１、２、５年和８年，ＡＬＴ复常者的抗－ＨＣＶ阴转率分别为１０％、６％、１６％和２２％。病后８年抗－ＨＣＶ阳性者的ＨＣＶＲＮＡ阳性率为８４％，其中ＡＬＴ异常和正常者无明显差异，绝大多数为基因Ⅱ型。８年时未检出ＡＦＰ异常者，肝功（血清胆红素和白蛋白）９６％～９７％为ＨｏｂｂｓⅠ级，甲胎蛋白＜２０ｎｇ，表明还没有明显的失代偿性肝硬化和肝细胞癌者。
163 cases
of hepatitis C was followed-up for 8 years.The rates of abnoimal ALT
were 100%, 73%, 57 %, 37% and 28 % in 1,1,2, 5 and 8 years
respectively after onset,two types of ALT dynamics showee,persistent
and fluctuation,the latter was for about 1/3 to 1/2.The positive
rates of anti-HCV were 56%,93%, 94%,96%, 97%, 93% ang 83% in 2,2～6,
6～12 months,1,2,5 and 8 years respectively after onset.The
sero-conversion of positive to negative of anti-HCV were only found
in a few patients whose ALT had re-covered to normal level and the
rates of this conversion were 10Ok, 8%,16% and 21% in 1,2,5 and 8
yearsafter onset. After 8 years positive rate of HCV RNA detected by
nested PCR was 84%in patients of anti-HCV positive,and no significant
differrence showed between patients with abnormaI ALT(80%) and
normalALT(85%)The genotype Il of HCV RNA accounted for 93%,In 8 year
follow up,no patients had devel-oped heptocellular carcirioma or
decompensation cirrhosis.
出处
《肝脏病杂志》
CSCD
1994年第4期222-224,共3页
