摘要
目的探讨ATⅡ含量和ACE活性是否与动物年龄的增长存在着相关性及牛磺酸(Taurine)对高血压的预防作用机理。方法对不同周龄大鼠和补充不同水平牛磺酸和β丙氨酸(牛磺酸转运抑制剂)大鼠血液中血管紧张素Ⅱ(angiotensinⅡ,ATⅡ)含量和血管紧张素转换酶(angiotensinconvertingenzyme,ACE)活性进行比较。结果随着大鼠年龄的增长血液中ATⅡ含量随之增高(p<0.05),ACE活性也随之增加(p<0.05),补充牛磺酸后使血液中ATⅡ含量、ACE活性降低(p<0.05)。结论给动物补充牛磺酸对高血压的产生具有预防作用。
Objective To explore whether the Angiotensin Ⅱcontent and angiotensin converting enzyme (ACE) activity are related with the age of animals and if taurine may exert preventive effects on the development of hypertension and the mechanisms of action. Methods Six 4 weeks Wistar rats, six 12 weeks rats and 56 60 weeks rats (male to female ratio 1∶1) were included in this study. The animals were fed with varying content of taurine and β alanine, a taurine transport inhibitor, for 8 weeks. The angiotensin Ⅱlevel and angiotensin converting enzyme activity at the end of 4 weeks and 8 weeks of experiment were assayed and analyzed. Results The content of angiotensin Ⅱand the activity of ACE were increased along with the increase of age( P <0 05). Supplement with taurine decreased both the content of angiotensin Ⅱand ACE activity in the rats (P <0 05). Conclusion Properly supplement with taurine may play a preventive role on the development of hypertension in animals.
出处
《中国比较医学杂志》
CAS
2005年第3期147-149,共3页
Chinese Journal of Comparative Medicine
基金
国家自然科学基金项目(C0203040)
