摘要
目的 以缺铁大鼠为模型研究了甘氨酸亚铁改善营养性贫血的效果。方法 选择体重5 0 (6 0克二级雌性断乳Wistar大鼠,给予低铁基础饲料耗空3周后,经尾静脉取血,测定血红蛋白含量,按尾血血红蛋白含量,把动物随机分为空白对照组、给予低剂量组、中剂量组、高剂量甘氨酸亚铁组和乳酸亚铁对照组,实验期为4周,测定动物生长发育指标和缺铁性营养性贫血相关指标。结果 补充甘氨酸亚铁显著改善大鼠生长,补充组的终体重和净增重显著高于低铁对照组;甘氨酸亚铁显著升高贫血大鼠的血红蛋白水平,而红细胞内游离原卟啉水平显著降低,补充甘氨酸亚铁组的脾脏铁含量和总铁含量均显著高于低铁对照组,并且与相同剂量的乳酸亚铁相比没有显著差异。结论 甘氨酸亚铁作为一种较理想的补充铁的营养强化剂,可明显改善缺铁性营养性贫血。
Objective In order to evaluate the efficacy of glycine chelated iron (Ⅱ) in improving nutritional anemia in rats. Methods After weaning wistar rats, weighing 50-60g, were fed the iron deficient diet for three weeks, whole blood was taken from rat's tail to measure Hb, then the rats were randomly divided into five groups by Hb, that is the control group fed with iron deficient diet, three groups fed the diets supplemented with different glycine chelated iron (Ⅱ), and another group fed with the diet added with lactate iron. Each group was fed respective diets for four weeks and indicators related to iron-deficient nutritional anemia were evaluated. Results The addition of glycine chelated iron (Ⅱ) did improve the growth and development of rats, increase the hemoglobin level and the iron retention in spleen, decrease free erythrocyte protoporphyrin (FEP) content in whole blood, and there was no significant difference between three supplemental groups with glycine chelated iron (Ⅱ) and the group with lactate iron. Conclusion glycine chelated iron (Ⅱ) can be used as a reasonable iron supplement in improving iron-deficient nutritional anemia.
出处
《卫生研究》
CAS
CSCD
北大核心
2005年第3期344-346,共3页
Journal of Hygiene Research
关键词
甘氨酸亚铁
贫血
铁
大鼠
Glycine chelated iron (Ⅱ), anemia, iron, rat
