摘要
目的:探讨中药复方柔肝软坚冲剂对四氯化碳中毒性肝纤维化的治疗作用。方法:复制大鼠四氯化碳肝纤维化模型,以鳖甲煎丸作阳性对照组,经柔肝软坚冲剂干预后分别用生化法检测大鼠血清丙氨酸转移(ALT)、血清白蛋白(ALB),放免法检测血清透明质酸(HA)、层粘蛋白(LN)及Ⅳ型胶原(C-Ⅳ)。同时观察大鼠肝组织病理学变化。结果:柔肝软坚冲剂可显著降低大鼠血清ALT,HA,LN及C-Ⅳ水平,升高ALB活性。病理组织学检查表明,用药各组肝纤维病理变化明显减轻。结论:柔肝软坚冲剂对实验性肝纤化大鼠肝细胞有保护作用及抗肝纤维化作用。
Objective: To explore the effect of Rouganruanjian granule powder in treatment of liver fibrosis induced by carbon tet-rachloride (CC14). Method: The rat models of liver fibrosis were induced by CC14, and being treated with Rouganruanjian granule powder in experimental group and with Biejiajianwan in positive controlled group. After interference of Rouganruanjian granule powder, the rats ALT and ALB were determined by the biochemical test, the hyaluranic acid (HA) , laminin(LN) , and collagen Ⅳ (C-Ⅳ) were determined by the radioimmunoassay, the change of histopathology in rats'was observed at same time. Result: After the treatment with Rouganruanjian granule powder, the serum levels of ALT, HA, LN and C-Ⅳ of the rat's models significantly decreased, and ALB elevated. Furthermore, the pathologic lesions of hepatic fibrosis also significantly improved in post-treatment. Conclusion: Rouganruanjian granule powder has a protective effect of hepatic cells and a effect againstg liver fibrosis in rat with experimental liver fibrosis.
出处
《中国药师》
CAS
2005年第6期449-451,共3页
China Pharmacist
关键词
柔肝软坚冲剂
肝纤维化
大鼠
Rouganruanjian granule powder
Liver fibrosis
Rat
