摘要
目的:探讨合适剂量的佳苏仑用于静吸复合全麻后既有较好催醒效果,又能保持生命体征平稳及减少不良反应。方法:60例静吸复合全麻病人随机分A 、B 、C三组,全麻后催醒首剂佳苏仑分别为0.5 mg/kg、1.0 mg/kg和1.5 mg/kg。记录用药前,用药后2 min、5 min、10 min、15 min血压、心率、呼吸次数、潮气量等生命体征数据;观察神志恢复情况及不良反应。结果:患者血压、心率用药后较用药前有不同程度上升,但无显著性差异(P>0.05),B组C组各有2例、5例患者血压、心率上升超过用药前20%以上,未给特殊处理20 min后自行恢复正常;所有病例呼吸次数、潮气量用药后较用药前明显增加(P<0.05),B、C组在5 min、10 min、15min增加明显高于A组(P<0.05);B、C组各有1例和3例出现恶心、出汗、肌肉抽搐,C组1例病人出现惊厥。各组在用药后10 min、15 min共有42例(70%)和47例(78.3%)患者清醒,B、C组5min、10min、15min清醒率明显高于A组(P<0.05)。结论:静吸复合全麻后静注佳苏仑1 mg/kg有较好的催醒和呼吸抑制逆转作用,副作用的发生也较少,是较理想的催醒药物剂量。
Objective:To find the most appropriate dosage of Doxapram Hydrochloride Injection used in arousing patients after general anesthesia via veins and gas.Methods:Sixty patients who would undergo general anesthesia via veins and gas were divided into three groups randomly.After anaethesia,Doxapram Hydrochloride Injection was used,the first dosages of them were 0.5mg/kg,1.0 mg/kg and 1.5 mg/kg.The vital signs,the degrees of wakefulness and side-effects such as convulsion,headache, sweating, nausea and itching were recorded.Results:After treatments the blood pressures and heart rate increased very little(P>0.05),and the incresments in group B and C were much stronger than that in group A at 5th min,10th min and 15th min(P< 0.05);Some side-effects such as nausea, sweating, and itching were found in 1 patient of group B and 3 patients of group C.There was 1 patients of group C was found convulsing.After the treatment with Doxapram Hydrochloride Injection there were 42 patients(70%)at 10th min and 47 patients(78.3%)at 15th min were awake,but the rates of them in group B and C at the time of 5th min,10th min and 15th were much higher than that in group A(P<0.05).Conclusion:One mg/kg Doxapram Hydrochloride Injection injected via veins is good for patients who have undergone general anaesthesia via veins and gas.
出处
《实用临床医学（江西）》
CAS
2005年第5期51-53,共3页
Practical Clinical Medicine
关键词
不同剂量
佳苏仑
静吸复合全麻
催醒
Iifferent dosage
doxapram hydrochloride injection
general anaesthesia via veins and gas
awake
