摘要
目的 探讨抑癌基因p5 3在子宫内膜癌发生、发展过程中的作用。方法 采用免疫组化ABC法检测37例子宫内膜癌、2 0例子宫内膜腺瘤样增生、18例子宫内膜单纯性增生、2 8例正常子宫内膜标本的抑癌基因 p5 3的表达。结果 p5 3表达阳性率 :子宫内膜癌为 48.6 5 % ;子宫内膜腺瘤样增生为 10 % ,显著低于子宫内膜癌 (P <0 .0 1) ;单纯性增生子宫内膜及正常子宫内膜均为阴性。子宫内膜癌病理组织学分级G1级 p5 3阳性表达率为13.33 % ,显著低于G2级 6 6 .6 7% (P <0 .0 1) ;而G2级又低于G3级 p5 3阳性表达率 (80 % ) (P <0 .0 5 )。在子宫内膜癌的手术分期中一期p5 3阳性表达率为 32 % ,显著低于二期以上的 83 .33% (P <0 .0 1)。子宫内膜癌局限于子宫内膜组p5 3阳性表达率为 9.1% ,低于癌侵润肌层组的 5 0 % (P <0 .0 5 )。p5 3表达阳性的子宫内膜癌患者 3年、5年生存率显著低于表达阳性的患者 (P <0 .0 1)。结论 抑癌基因p5 3在子宫内膜癌发生、发展的不同阶段起作用 ,与子宫内膜癌生物学行为相关 。
Objective To study the action of the suppressor gene p53 in the process of occurrence and development of endometrial cancers.Methods Overexpresssion of suppressor gene p53 was studied by immunohistochemistry ABC method in 37 patients with endometrial carcinoma,20 with endometrial adenomatoid hyperplasia,18 with endometrial simplex hyperplasia and 28 with normal endometrial specimens.Results p53 protein positive expression rate was 48.65% in endometrial carcinoma;it was 10% in endometrial adenomatoid hyperplasia and significance was lower than that in the endometrial carcinom ( P <0.01),p53 overexpression was negative in endometrial simplex hyperplasia and normal endometrium.The rate was 13.33% in FIGO G1 and lower significantly than the rate in FIGO G2 which was 66.67%( P <0.01);The rate was 80% in FIGO G3 and higher than that in FIGO G2 ( P <0.05),In the operation stages of endometrial carcinoma,the rate was 32% in the first stage and lower significantly than the rate in the second stage and the stages above the second which was 83.33% ( P <0.01).The rate was 9.1% in the group of carcinoma which was localized endometrium and lower than the rate in the group of muscle invaded by carcinoma which was 50% ( P <0.05).The number of patients with survival rate of 3~5 years,whose p53 overexpression was positive was lower than that of the patients whose p53 overexpression was positive ( P <0.01).Conclusion Suppress gene p53 has effect in the different stages of endometrial carcinoma occurrence and development,it is releyant to the biology action of endometrial carcinoma and it has clinical significance in the judgement prognosis and remedial treatment choice in the treatment of endometrial cancers.
出处
《苏州医学院学报》
2000年第10期899-901,共3页
Acta Academiae Medicinae Suzhou