摘要
本文对４２例重症肌无力（ＭＧ）患者及４０例正常对照外周血单个核细胞分必ＩＬ－１活性进行了检测，并对１４例ＭＧ患者在应用糖皮质激素（ＧＣ）一月后ＩＬ－１活性变化进行了观察。结果：ＭＧ患者ＩＬ活性明显高于正常对照，ＭＧ患者ＩＬ－１活性变化与ＡｃｈＲａｂ产生密切相关，与ＭＧ临床类型、病情、愈后密切相关，ＧＣ治疗后ＩＬ－１活性明显降低。结果提示ＩＬ－１参与了ＭＧ的发生、发展，检测ＩＬ－１活性对指导ＭＧ临床有重要的参考价值，ＧＣ可能通过抑制ＩＬ－１参与了ＭＧ的发生、发展，检测ＩＬ－１活性对指导ＭＧ临床有重要的参考价值，ＧＣ可能通过抑制ＩＬ－１活性而发挥其免疫治疗作用。
Interleukin 1(IL-1)production of peripheral blood mononuclear cells(PBMC) were measured in 40 normal control(NC) and 42 patients with myasthenia gravis(MG),measured again in 14 of all MG patients after using glucocorticosteroids(GC).Results showed that: IL- 1 production of PBMC of MG patients was much higher than that of NC. The variation of IL-1 production of MG patients were related to not only the producing of AchRab but also the clinical types ,disease severity and progression of MG. The producing of IL-1 was significantly decline in 14 MG patients after using GC . Results indicate that: IL1 plays an important role in the pathogenetic mechanisms of MG.Defectiving IL-1 are much useful in monitoring clinic of MG. The immunol inhibiting role of GC on MG patients is produced by effecting producing of IL-1.
出处
《卒中与神经疾病》
1995年第3期126-128,130,共4页
Stroke and Nervous Diseases
