摘要
目的观察辛伐他汀治疗老年不稳定性心绞痛对患者血清胆固醇及高敏C反应蛋白(high-sensitivityC-reactiveprotein,hs-CRP)的影响。方法将78例(73±7岁)老年不稳定性心绞痛患者,分为辛伐他汀组和对照组。辛伐他汀组(45例)给予辛伐他汀(20mg/天),治疗共4周;对照组(33例),常规(未经调脂)治疗。分别测定治疗前后的血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)及hs-CRP,统计学比较两组治疗前后血清TC、LDL-C、HDL-C及hs-CRP水平。结果①治疗前两组血清TC、LDL-C、HDL-C及hs-CRP水平均无显著差异(P>0.05)。②辛伐他汀组治疗后TC、LDL-C显著下降(P<0.001),HDL-C升高(P=0.002)。对照组治疗前后TC、LDL-C、HDL-C均无显著性差异(P>0.05)。③辛伐他汀组与对照组治疗后hs-CRP均有下降,但辛伐他汀组下降值(2.91±2.62mg/L)显著大于对照组下降值(0.91±1.18mg/L)(P<0.001)。④辛伐他汀治疗4周后hs-CRP的降低与血脂改变TC(r=0.004P=0.977)、LDL-C(r=0.173P=0.256)、HDL-C(r=-0.223P=0.141)无相关性。结论辛伐他汀治疗老年不稳定性心绞痛患者4周,能安全有效调节血清胆固醇及降低hs-CRP水平,且降低hs-CRP水平独立于其调脂作用。
Objective To observe the effects of simvastatin on serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and high sensitivity C-reactive protein (hs-CRP) in elderly with unstable angina (UA). Methods Seventy-eight cases ( average age 73±7 years) UA were divided into simvastatin group (45 cases) and control group (33 cases). The serum TC, LDL-C, HDL-C and hs-CRP were detected before and after treatment. Results (1) There was no significant difference of serum TC, LDL-C, HDL-C, hs-CRP between two groups before treatment (P > 0.05). (2) The serum TC, LDL-C significantly decreased (P < 0.001) and the serum HDL-C increased (P = 0.002) in simvastatin group after treatment. No changes of serum TC, LDL-C, HDL-C were observed in control group (P > 0.05) after treatment without simvastatin. (3) Serum hs-CRP significantly decreased in both groups (P <0.001). But the reduction of hs- CRP in simvastatin group (2.91±2.62mg/L) was significantly greater than that in control group (0.91±1.18mg/L)(P <0.001). (4) There was no relation between the reduction of hs-CRP and the changes of TC(r=0.004, P =0.977)、LDL-C(r=0.173, P = 0.256)、HDL-C(r=-0.223, P =0.141) after simvastatin treatment. Conclusions Treatment with simvastatin (20mg/d) for 4 weeks in elderly UA can lower serum hs-CRP in a lipid-independent manner.
出处
《老年医学与保健》
CAS
2005年第2期94-96,共3页
Geriatrics & Health Care
