摘要
作者研究了月桂氮酮的合成，确定以月桂醇为起始原料经溴代反应和Ｎ－烷基化反应，合成了月桂氮酮，总收率可达７８％。其中Ｎ－烷基化反应考虑到成本、操作方便等因素，使之能适应国内工业化生产的实际需要，选择了液－液相转移催化方法。经实验研究表明：以６５％～７０％氢氧化钠溶液为缩合剂，经ＴＢＡＢ为相转移催化剂，其收率可达９０％。
Laurocapram was prepared by bromination and N-alkylation of liquid-liquid phasetransfercatalysis(PTC)from lauryl alcohol. The yeild was 78%.The experimentals of N-alkylation of PTCindicate that the yeild is 90% with condonsed agcnt (65%～70%NaOH solution)and catalyst(TBAB).This method is adapted to the needs of industrial production.
出处
《重庆医科大学学报》
CAS
CSCD
1994年第1期12-14,共3页
Journal of Chongqing Medical University
关键词
月桂氮卓酮
氮酮
相转移催化
合成
Laurecapram
Azone
Synthesis
Bromination
N-alkylation,Liquid-liqutd PTC
