摘要
３－甲基－２－丁酮、芳香醛和芳香胺在少量浓盐酸的催化下能直接进行Ｍａｎｎｉｃｈ反应，并用一步法合成了３－甲基－１－芳基－１－芳胺基－３－戊酮。所合成的１２个新化食物，产率高达６１～８７％。本文还讨论了３－甲基－２－丁酮、芳香醛及芳香胺的结构与Ｍａｎｎｉｃｈ反应的关系。
In the presence of catalytic amount of hydrochloric acid,the Mannich reaction of 3-methyl-2-butanone , aromatic aldehydes and aromatic amines can be carried out directly at 0～20℃. Twelve corresponding Mannich bases(Ia～I1),3-methyl-1-aryl-1-arylamino-3-pentanones,were prepared. The yields were 61%～87%、The relation between the Mannich reaction and thestructure of 3-methyl-2-butanone,aromatic aldehydes and aromatic amines is also discussed in thispaper.
出处
《重庆师范学院学报（自然科学版）》
1994年第1期20-25,共6页
Journal of Chongqing Normal University(Natural Science Edition)
关键词
芳香醛
芳香胺
芳胺基戊酮
甲基
methyl-2-butanone,aromatic aldehydes, aromatic amines, Mannich rcaction,Mannich bases
