摘要
用三甲基胆蒽皮下诱发小鼠肉瘤，观察亚硒酸钠与维生素Ｅ对此肉瘤发生的影响。结果表明，亚硒酸钠组小鼠，延缓肉瘤发生时间，与对照组比较肉瘤发生率由５３．３％降至２７．７％，维生素Ｅ组，无降低肉瘤发生作用。亚硒酸钠与维生素Ｅ联合应用组肉瘤发生率与亚硒酸钠组相似，亚硒酸钠组能明显升高小鼠血中谷胱甘肽过氧化物酶的活性及血中硒的含量，维生素Ｅ无此作用。结果说明亚硒酸钠与维生素Ｅ虽都为抗氧化剂，并都被认为有防癌作用，但它们对本实验三甲基胆蒽皮下诱发肉瘤的作用似不相同。
Abstract In the present study, sarcomas in mice were induced by subcutaneous injections of 3-methylcholanthrene(3-MCA) and the effect of sodium selenite(Se) and vitamin E(VE) on the development of sarcomas were observed.In the mice suplemented with 2. 5 ppm Se in drinking water,the appearnce of sarcomas was delayed and the incidance rate was reduced to 27. 7% in comparision with 53. 5% in the comtrol. However, 1 g of VE per kg of diet did not influence the incidance rate of sarcomas. A combination of Se and VE did not show a increased inhibitory effect on the development of sarcomas than Se used alone.The levels of glutathione peroxidase and Se in bind were significantly elevated by Se supplemention,while no changes occured in the VE grouch. It is well known that Se and VE are antioxidizing agents which may produce cancer preventive effect in some animal modele but,in our experiments,different results were observed in the development of mouse subcutaneous sarcomas induced by 3-MCA.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
1994年第2期67-69,共3页
Cancer Research on Prevention and Treatment
