摘要
一次极量注射顺铂后，检测超氧化物歧化酶（ＳＯＤ）、维生素Ａ（ＶＡ）保护兔及对照兔血尿素氮（ＢＵＮ）、肌酐（Ｃｒ）、２４小时尿蛋白（ＵＰ）、耳血粒细胞计数。结果发现ＳＯＤ保护组及ＶＡ保护组兔ＢＵＮ、Ｃｒ、ＵＰ检测值明显低于对照组（Ｐ＜０．０１）．而粒细胞计数高于对照组（Ｐ＜０．０５）．说明ＳＯＤ及ＶＡ能保护肾及骨髓，免受顺铂所致的损伤。实验结果为临床大剂量应用氧自由基抗癌药，减少毒性，提高疗效，提供了新的方法。
A single maximum dose of cisplatin was injected into rabbits vein. Group A rabbits were treated with superoxide dismutase (SOD),group B with vitamin A(VA),and group C as the control. Blood urea nitrogen(BUN), creatinine(Cr), 24h urea protein(UP) and blood granulocyte were determined.The quantities of BUN,Cr and UP of group A and B were significantly lower than the control(P<0.01).Whereas granulocyte count was higher(P<0.05).The result suggested the SOD and VA could prevent the damage caused by cisplatin to kidney and bone marrow,and opened a complemental way for physicians in using maximal dosage of anticancer drugs which are free radicals producing.
出处
《肿瘤》
CAS
CSCD
北大核心
1994年第6期323-326,共4页
Tumor
