摘要
目的了解本地区妊娠肝内胆汁淤积症(intrahepatic cholestasis of pregnancy,ICP)的发病率及发病特点.方法从妊娠20～24周开始普查,动态观察至36周以上,以总胆汁酸酶循环法测定血清总胆汁酸(total bile acid,TBA),TBA＞28.5μmol/L为异常,同时复查肝功能加以确诊.结果共普查1275例,确诊为ICP的患者102例,发病率为8.00%.妊娠33～36周ICP的发病率(66/351,18.80%)明显高于其他不同孕龄组(P＜0.01).少数民族孕妇ICP的发病率(47/328,14.33%)高于汉族孕妇(55/947,5.81%)(P＜0.01).有ICP高危因素的患者ICP发病(10/67,14.93%)高于无高危因素组(92/208,7.62%)(P＜0.01).结论克拉玛依地区ICP的发病率为8.00%,为ICP的高发地区.少数民族孕妇ICP的发病率明显高于汉族发病率.ICP的发病与孕周、孕妇年龄、家族、服药史等有一定的相关性.TAB在整个孕期的波动范围较大.
Objective To investigate the incidence and epidemiologic characteristics of intrahepatic cholestasis of pregnancy (ICP) in Karamy area. Methods From 20~24 gestational weeks, 1275 women were followed up till 36 weeks or later. Serum total bile acid (TBA) level was measured by serum total bile acid cycle assay. Diagnosis of ICP was according to elevated TBA level (>28.5 μmol/L) and liver function. Results Among 1275 women, 102 were diagnosed with ICP giving an incidence of 8.0%. The incidence was significantly higher during 33 to 36 weeks (18.80%, P<0.01) than that of 20 to 32 weeks group and ≥37 weeks group. A significantly higher incidence of ICP was found in the ethnic minority groups including Uighur and Hui etc. than that of Han Chinese (14.33% vs 5.81%, P<0.01). Those women who with high risk factors showed a higher incidence of ICP than those without (14.93% vs 7.62%, P<0.01). Conclusions Karamy is a high prevalent area of ICP with the incidence of 8.0% and the ethnic minority pregnant women has a higher incidence than that of the Han Chinese. The occurrence of ICP is associated with gestational week, maternal age, maternal ethnicity, family history and medication. The level of TBA varies a lot during pregnancy.
出处
《中华围产医学杂志》
CAS
2005年第3期165-167,共3页
Chinese Journal of Perinatal Medicine
