摘要
目的观察6种常用的调理脾胃方药补中益气汤、大承气汤、归脾汤、温胆汤、瓜蒂散、草果知母汤对脑内单胺类神经递质,包括去甲肾上腺素(NE)、多巴胺(DA)、5-羟色胺(5-HT)以及代谢产物5-羟吲哚乙酸(5HIAA)、高香草酸(HVA)含量的变化。方法分别给予大鼠6种中药汤剂灌胃,15d后,采用高效液相-电化学法检测大鼠脑内单胺类递质的含量。结果补中益气汤、归脾汤可增加脑组织NE的含量,大承气汤有降低皮层和海马NE的作用,草果知母汤可降低海马DA的含量,温胆汤则可降低皮层DA的含量,瓜蒂散可升高皮层NE含量。结论不同的调理脾胃方药作用于单胺类递质的部位和趋势有所不同:温补和吐泻的调理脾胃药以作用于NE系统为主,调畅气机的脾胃药以作用于DA系统为主。
Objective To observe the influence of six prescriptions for regulating spleen_stomach,including Buzhongyiqi Decoction,Dachengqi Decoction,Guipi Decoction,Wendan Decoction,Guadi Powder and Caoguozhimu Decoction on the content changes of monoaminergic neurotransmitter(MN),such as NE,DA,5_HT,5_HIAA and homovanillic acid (HVA).Method Rats were given above 6 prescriptions respectively and the contents of MN in their brains were detected by HPLC_electrochemistry after 15 days.Results Buzhongyiqi Decoction and Guipi Decoction increased NE content in cerebral tissue,Dachengqi Decoction decreased NE content in rat cortex and hippocampus,Caoguozhimu Decoction decreased DA content in rat hippocampus,Wendan Decoction decreased DA content in rat cortex and Guadi Powder increased NE content in rat cortex.Conclusion The effects of different prescriptions on rat MN have different position and trend.The prescriptions with warming,reinforcing and emetocatharsis effects mainly influence on NE system,and those with activating qi effect mainly influence on DA system.
出处
《北京中医药大学学报》
CAS
CSCD
北大核心
2005年第3期31-34,共4页
Journal of Beijing University of Traditional Chinese Medicine
基金
国家中医药管理局重点学科211子项目(No.20013)
关键词
调理脾胃方药
单胺类递质
多巴胺
5-羟色胺
5-羟吲哚乙酸
prescription for regulating spleen_stomach
monoaminergic neurotransmitter
dopamine
5_hydroxytryptamine
5_hydroxyindoleacetic
