摘要
通过自行设计的超临界CO2微球制备装置,利用乙基纤维素丙酮混合溶液,制备了粒径偏差较小、表面光滑与球形度较好的乙基纤维素微球,采用正交试验讨论了温度、压力、溶液质量浓度、CO2流量对微球粒径与粒径分布的影响,分析了进气与进液方式对试验过程的影响。试验结果表明:改变工艺参数,可在较大范围内调控微球大小,所制微球平均粒径为0.2—2.6μm,粒径偏差为0.07—0.85μm;溶液质量浓度是主要影响因素;不同的汽液接触方式也将影响微球的大小。
On a self-designed experimental apparatus of supercritical CO_2 antisolvent precipitation, the ethyl cellulose microspheres were obtained with the solution of ethyl cellulose and acetone, which is featured by smooth surface, good sphericity and less deviation in standard microspheres size. The effects of temperature, pressure, liquid solution mass concentration, CO_2 rate on the size and the morphology of ethyl cellulose microspheres were studied through orthogonal test, and the effects of the joining method of gas and liquid were also analyzed. The result shows that the SAS process can control the size and the morphology of ethyl cellulose microspheres, the mean diameters of the microspheres ranging between 0.2 and 2.6 μm can be obtained, and the standard deviation of microspheres size was 0.07—0.85 μm; the mass concentration of the liquid has a major influence upon the size and the morphology of final product; and the joining method of liquid and gas can change the size of the microspheres.
出处
《化学工程》
EI
CAS
CSCD
北大核心
2005年第3期63-67,共5页
Chemical Engineering(China)
基金
国家自然科学基金资助项目(59836240)
上海市教委重点学科建设项目
关键词
超临界CO2抗溶剂法
乙基纤维素
微球
药剂学
supercritical CO_2 antisolvent precipitation
ethyl cellulose
microspheres
pharmaceutics
