摘要
目的 探讨高血压患者的脉压对冠心病发生的预测价值。方法 分析2 2 4例因胸痛而接受冠状动脉造影的高血压患者,其中男1 1 6例,女1 0 8例,年龄44～80 (63±8)岁。外周肱动脉测定收缩压、舒张压并求得脉压,冠状动脉造影结果冠状动脉管腔内径狭窄≥5 0 %诊为冠心病,比较脉压与冠心病发生的关系。结果 2 2 4例中,1 1 4例根据冠状动脉造影结果诊为冠心病。冠心病组除年龄、高血压病程和其他冠心病危险因素(吸烟、糖尿病)比例上显著高于无冠心病组外,两组的各种血压参数(除舒张压)也存在显著性差异。多因素逐步回归分析结果显示,脉压、收缩压和吸烟是冠心病发生的独立预测因素。其他各种参数与冠心病发生无明显相关性。结论 脉压是反映大动脉弹性的参数,是与冠心病发生相关的一个重要和独立的因素,可作为全身心血管病的一个危险信号,以指导早期干预。
Objective To determine whether pulse pressure (PP) is an independent and important predictor for coronary artery disease(CAD) in essential hypertensive patients. Methods Parameter of blood pressure, clinical features and coronary angiographic findings were analyzed retrospectively in 224 patients with essential hypertension (116 male,108 female , mean age 63±8 years old). Brachial systolic and diastolic blood pressure was measured in all patients. Patients with CAD were diagnosed by coronary angiography(lumen diameter narrowing≥50%). Results Among 224 patients, 114 patients (50.9%) had CAD and 110 patients (49.1%) had normal coronary arteries. There was significant difference in age, duration of hypertension, incidenceof other risk factors (smoking, diabetes) and parameters of blood pressure (except diastolic blood pressure) between patients with CAD and without CAD. Multiple stepwise regression analysis showed that PP, systolic blood pressure and smoking were strongly correlated with incidence of CAD in essential hypertensive patients. Conclusions PP was the simplist parameter reflecting large artery elasticity and closely related to severity of CAD. This parameter could be a predictor of cardiovascular risk and instructing early intervention.
出处
《心脑血管病防治》
2005年第3期7-8,13,共3页
CARDIO-CEREBROVASCULAR DISEASE PREVENTION AND TREATMENT
关键词
高血压
脉压
冠心病
Hypertension
Pulse pressure
Coronary artery disease
