摘要
报告常规剂量联合化疗治疗骨髓增生异常综合征（ＭＤＳ）及其继发性急性髓系白血病（ＳＡＭＬ）１７例，完全缓解率３５％，部分缓解率１２％，总有效率４７％。证明对ＭＤＳ患者有选择性地采用常规剂量联合化疗是可行的。此外，还对化疗期间骨髓变化过程及毒副反应进行了观察。
he in vitro growth of bone marrow blast cellprogenitors (BCP) was studied in 27 patients withmyelodysplastic syndromes (MDS). The bone marrowmononuclear cells used in cultures were deprived of T-lymphocytes and monocytes, and phytohemagglutininleukocytes-conditioned medium (PHA-LCM) was usedas stimulator. Blast cell colonies (BCC) were found in10 (37%) out of 27 MDS patients. There weresomewhat relationships between BCC growth and MDSsubtypes. The BCC growth rates correlated significantlywith sister chromatid differentiation. No BCC wasobserved in the controls. Our results showed that theBCP might reflect the malignant clone in MDS, andBCC be an important index to evaluate the disease stageof MDS.
出处
《中华血液学杂志》
CAS
CSCD
北大核心
1994年第7期349-352,共4页
Chinese Journal of Hematology
关键词
骨髓增生异常
白血病
药物疗法
Myelodysplastic syndromesPhytohemagglutinin leukocytes-conditioned medium Blast cellcolones
