摘要
以胃粘膜的反复损伤作为发病条件，结合致癌剂（ＭＮＮＧ），在大白鼠上引发癌前病变和胃腺癌。结果，胃粘膜上皮异型增生表现类型可为腺瘤型、隐窝型、再生型和囊型。ＤＮＡ定量显示，异型增生上皮与正常胃粘膜存在显著性差异，重度异型增生与高分化腺癌间没有截然界限。从异型增生与胃癌发生关系来分析，胃粘膜异型增生为重要的癌前病变，各类型均有重要的癌前意义。其中再生型异型增生的癌前意义应被重新认识和重视。
or
producing precancerous lesions and gastric cancer,227 inbred Wistar rats were giventraumatic
factor(40%alcohol)and carcinogen(100 μg/ml MNNG)for 20 weeks.The resultsshowed that
gastric dysplasia is the apparent form of precancerous lesion of gastric cance.The
histopathological types of gastric dysplasia might be classified as follows:
adenomatousdysplasia,crytal dysplasia,regenerative dysplasia and cystiform dysplasia.The
nuclear DNAcontents didn’t show significant statistical differences between each of the
phenotypes ofgastric dysplasia,but increased steadily as the degree of dysplasia advances
from mild,moderate and severe up to differentiated adenocarcinoma.It was found that there was
asignificant statistical difference between the nuclear DNA content of mild dysplasia and thatof
normal gastric mucosa(P<0.05).It means that an analysis of DNA content can be used
fordifferentiating a normal mucosa from dysplasia,but there isn’t a sharp boardline between
thedysplasia of severe degree and differentiated adenocarcinoma.The morphogenesis of 33
casesof gastric adenocarcinoma was analyzed.The results suggest that various phenotypes
ofgastric dysplasia have similar precancerous significance and the precancerous significance
ofregenerative dysplasia should again be considered seriously.
出处
《中华消化杂志》
CAS
CSCD
北大核心
1994年第4期216-219,共4页
Chinese Journal of Digestion
基金
上海市青年自然科学基金
关键词
胃粘膜
异型增生
动物实验
胃肿瘤
Stomach
Dysplasia
Histopathological type
Carcinoma
Animal experi- ment.
