摘要
本文报道用ＩＬ－２及抗肿瘤ｉＲＮＡ作用于人胎儿肝、脾、胸腺及成人外周血淋巴细胞，用ＬＤＨ释放法测定其对Ｋ５６２及ＡＧＺＹ－８３ａ的杀伤作用，结果胎脾、肝效应细胞活性与成人外周血无显著差异，胸腺效应细胞的活性低于上述细胞。ＩＬ－２与ｉＲＮＡ联合诱导的效应细胞杀伤活性显著高于二者单独应用的活性。
Human lymphocytes derived from fetal liver,spleen ’thymus,and peripheral blood were grown together withIL-2and antitumor immune RNA(iRNA),Separately and tested in a LDH enzyme release assay against target cellsK562 and AGZY-83a. The results showed that the activities of fetal liver,spleen effectors were not different fromthe one of PBL (p >0. 05).The activity of fetal thymal effectors was lower than the above mentioned(P<0.01). When the mentioned lymphocytes were incubated with IL-2and iRNA togther ,the antitumor activity could be aug-mented significantly(p<0.01)。
出处
《中华微生物学和免疫学杂志》
CSCD
北大核心
1994年第1期47-50,共4页
Chinese Journal of Microbiology and Immunology
关键词
白细胞介素2
肿瘤
抗肿瘤活性
IL-2
Tumor iRNA
Fetal spleen lymphocyte
Fetal liver lympocyte
Fetal thymal lymphocyte
Peripheral blood lymphocyte
