摘要
为探讨复方黄连降糖片(主药:大黄、黄连、肉桂等)对胰岛素抵抗型KK ay小鼠骨骼肌葡萄糖转运蛋白4(glucosetransporter 4,GLUT 4)基因表达的影响,将雄性KK ay小鼠,随机分为模型组、中药低剂量组、中药高剂量组、西药组,饲以高脂饮食;选用健康的雄性C57BL小鼠作对照,饲以普通饮食。用药两周后处死动物,测定各组的空腹血糖、血脂、血清胰岛素、GLUT 4mRNA表达。结果:KK ay小鼠在饲以高脂饮食后,血糖、血脂、血清胰岛素显著升高,同时骨骼肌GLUT 4mRNA的表达明显下降。治疗后血糖降低,血甘油三酯降低,骨骼肌GLUT 4mRNA表达明显增加。结论:复方黄连降糖片能改善胰岛素抵抗型KK ay小鼠的糖脂代谢紊乱,增加KK ay小鼠的骨骼肌GLUT 4mRNA表达。
To study the effects of “Fufang Huanglian Jiangtang Tablet” on GLUT 4 gene expression, KK ay mice were given high lipid diet and different doses of “Fufang Huanglian Jiangtang Tablet”. After modeling and treatment, the fasting blood sugar, blood lipid, serum insulin and GLUT 4 mRNA expression were detected. Results: After modeling, fasting blood sugar, blood lipid and serum insulin increased obviously, while GLUT 4 mRNA expression significantly reduced; after treatment, fasting blood sugar and blood triglyceride reduced, and GLUT 4 mRNA expression increased. It is showed that this Tablet can fight glucose and lipid metabolic disturbance, and increase GLUT 4 mRNA expression.
出处
《上海中医药杂志》
北大核心
2005年第6期48-50,共3页
Shanghai Journal of Traditional Chinese Medicine
基金
上海市科技发展基金资助项目(024119103)。
