摘要
作者观测了４３例门脉高压症患者股动脉血ＰＯ２、胃网膜有动静脉胃壁支血ＰＯ２、胃壁支静脉及肘静脉血ｐＨ、ＨＣＯ３－和胃网膜右静脉压力，其中２３例并有非出血期门脉高压性胃病。结果表明：①门脉高压症患者的股动脉血ＰＯ２低于对照组；②门脉高压症患者胃网膜右动静脉胃壁支血氧分压差低于对照组，胃网膜右静脉压力高于对照组，胃壁支静脉血ｐＨ和ＨＣＯ３－低于对照组和同组肘静脉血。并有门脉高压性胃病者这些变化更为显著。提示门脉高压性胃病的发病机制在于门脉系压力增高、胃粘膜下动静脉短路开放、胃粘膜缺血缺氧和胃壁局部酸中毒。
Model of gastric precancerous changes was made in rats by synthetical method which comprised inserting a spring into the pylorus and continual oral administration of MNNG solution for 4 months. There was significant difference between the model group and the normal group or the only administrating MNNG solation group in the indexes of bodyweight, bile acid content and pH value of gastric juice, pathology of gastric mucosa. The study indicated that the model made by synthetical method may be useful in studying the mechanism of gastric carcinogenesis and in observing the drug efficacy.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
1994年第5期307-308,共2页
Chinese Journal of Experimental Surgery
关键词
血液气体分析
门脉高血压
胃壁
Gastric neoplasm Precancerous lesion Precancerous condition Animal, experimental
