摘要
本文研究了梗阻性黄疸对兔淋巴细胞功能的影响及胆道内引流术后淋巴细胞功能恢复情况。结果发现胆总管结扎(CBDL)3周时兔淋巴细胞对植物血凝素(PHA)和刀豆素-A(Con—A)的刺激反应明显低于CBDL前(P<0.001);而且淋巴细胞用CBDL兔自身血浆培养时对分裂素原的刺激指数明显低于用CBDL前血浆培养(P<0.05和P<0.02),胆肠内引流术后4周,淋巴细胞对分裂素原刺激反应恢复到正常水平。结果提示梗阻性黄疸宿主血浆中存在细胞免疫抑制因子。
The study evaluates lymphocytic function in rabbits three weeks following common bile duct ligation (CBDL) and four weeks following relief of jaundice by internal biliary drainage. The results demonstrate depressed responsiveness to PHA (P<C 0.001) and to Con-A (P<0. 001) in vitro in CBDL rabbits as compared with before CBDL. When CBDL rabbits' lymphocyte incubated with 10% self rabbit serum after CBDL, responsiveness to PHA (P<0. 05) and to Con-A (P<0. 02) is significantly low compared with those incubated with 10% self rabbit serum before CBDL. This impairment is completely reversible at the end of the fourth week after internal biliary drainage. Our results suggest that there is plasma cellular-immune inhibitory factor in obstructive jaundiced hosts. The factor may be combined with lymphocytic membrane.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
1994年第1期9-10,共2页
Chinese Journal of Experimental Surgery
