摘要
本文探讨尿SDS-PAGE的诊断意义。正常人不同年龄组共110人,IgA肾病50例、肾病综合征200例、慢性肾衰100例、肾小管病变20例。结果:正常人17.3%为中分子型蛋白尿,63.6%为小分子型,无一例大分子型。IgA肾病混合型、大分子型蛋白尿者,病理损害程度都在Ⅱ级以上。肾病综合征86%为混合型,13%为大分子型。慢性肾衰53%为混合型,但36%为小分子型。肾小管损害,80%为小分子型。因此,仅凭尿SDS-PAGE有类似正常人的中、小分子型蛋白,而无大分子型者,不能武断为病理性,各型肾脏病的SDS-PAGE结果,都须结合临床分析。
The SDS-PAGE patterns of proteinuria were determined in normal individuals (n=110), patients with IgAN (n= 50), CRF (n=100), nephrotic syndrome (n=200) and renal tubular diseases (RTD) (n=20). The SDS-PAGF patterns were classified as low moleou-lar weight (MW), middle MW, high MW, mix and negative. Low MW and middle MW were found in 63.6% and 17.3% of healthy individuals res-pectively.All four patterns of proteinuria were identified in the pattients of CRF, NS and IgAN. Only low MW (80%) and middle MW (20%) patterns had been identified in the patients with RTD. A comparison with pathologic diagnosis of IgAN revealed that mix and high MW patte-rns had a tendency of more severe pathologic damage. In conclusion, HMW and mix pattern of SDS-PAGE have an important value for dia-gnosis, hut LMW and MMW pattern must be interpreted with clinical data.
出处
《中华肾脏病杂志》
CAS
CSCD
北大核心
1994年第2期77-79,共3页
Chinese Journal of Nephrology
关键词
肾病综合征
尿蛋白
免疫球蛋白
IgA Nephropathy, Nephrotic Syndrome, Proteinuria.
