摘要
我们观察了５５例尿毒症肾性骨营养不良症（简称肾性骨病，包括甲状旁腺功能亢进性骨病、低转化软骨病、混和性骨病）中血甲状旁腺激素（ＰＴＨ）、１．２５（ＯＨ）＿２Ｄ＿３、血钙、磷、ＡＫＰ、血铝及骨铝的变化。结果发现：各型肾性骨病血ＰＴＨ显著高于正常（Ｐ＜０．００１），血１．２５（ＯＨ）＿２Ｄ＿３和血钙显著低于正常（Ｐ＜０．００１）。在低转化软骨病组，血１．２５（ＯＨ）＿２Ｄ＿３显著低于甲旁亢骨病组（Ｐ＜０．０５）；血磷与正常对照无显著性差异，而显著低于甲旁亢骨病组及混合性骨病组（Ｐ＜０．０５）。ＰＴＨ与１．２５（ＯＨ）＿２Ｄ＿３呈线性负相关（Ｐ＜０．０５），而与ＡＫＰ呈线性正相关（Ｐ＜０．０５）。ＰＴＨ与血透时间、血钙、血铝及骨铝不相关。１．２５（ＯＨ）＿２Ｄ＿３与血透时间、血磷、血铝及骨铝不相关。骨铝染色阳性组与阴性组之间，ＰＴＨ、１．２５（ＯＨ）＿２Ｄ＿３及ＡＫＰ升高率均无显著性差异。
The changes of plasma PTH,1,25(OH)_2D_3.serum calcium, phosphorus and AKP were observed in55 uremic patients with renal osteodystrophy. The results showed that: In all types of renalosteodystrophy, plasma PTH were markedly higher than normal(P<0.001),while plasma 1,25(OH)_2D_3 and serum calcium were lower than normal(P<0.001).In low bone-turnover uremicosteodystrophy(LTO),plasma phosphorus was markedly lower than that of high bone-turnoveruremic osteodystrophy(HTO) and mixed uremic osteodystrophy(MO)(P<0.05),and plasma 1,25(OH)_2D_3 was significantly lower than that of HTO(P<005).In HTO and MO,serum phosphoruswas much higher than normal(P<0.001).Plasma PTH had a negative linear correlation with plasma 1,25(OH)_2D_3(P<0.05),a positive linear correlation with serum AKP (P<0.05),but no linear correla-tion with the duration of hemodialysis, serum calcium, serum aluminum and bone aluminum content.Plasma 1,25(OH)_2D_3 had no linear correlation with the duration of hemodialysis, serum phosphorus,serum aluminum and bone aluminum content.There was no significant difference in the plasma PTH,1,25(OH)_2D_3 and serum AKP between the bone aluminum stain positive and negative groups.
出处
《中华内科杂志》
CAS
CSCD
北大核心
1994年第1期33-36,共4页
Chinese Journal of Internal Medicine
