摘要
应用小剂量熟大黄（每日７５０ｍｇ），对妊娠中期体重指数＞０．２４，或平均动脉压（ＭＡＰ－２）＞１２ｋＰａ（９０ｍｍＨｇ）者（１４０例，大黄组）进行预防性用药，至分娩前停用，同时设立安慰剂组（１２５例）与对照组（６８例）。观察妊高征的发生、朋药前后血浆抗轻血酶ＩＩＩ（ＡＴＩＩＩ）、纤维结合蛋白（Ｆｎ）及纤溶酶原活性抑制因子（ＰＡＩ）水平的变化。结果：大黄组发生妊高征者８例（５．７％），低于安慰剂组的发生率（２０．８％），两组比较差异有非常显著意义（Ｐ＜０．０１）。服药９～１０周时，大黄组的血浆Ｆｎ、ＰＡＩ水平明显低于安慰剂组（Ｐ＜０．０５），大黄组朋药前后ＡＴＩＩＩ下降数值明显低于安慰剂组下降的数值（Ｐ＜０．０５）。提示：熟大黄有预防好高征发生的作用，其作用机理与抑制ＰＡＩ括性，降低血管内皮损伤有关。
prospective randomized double blind studywith proeessed rhubarb (low dose of 0.75g / day) wascarried out in pregnant women at risk of pregnancyinduced hypertension (PIH). Rhubarb (140 cases) orplaeebo (125 cases) was givcn to women at risk of PIHconsecutively from the 28th week of gestation till de-livery, and another 68 pregnant women as control. Re-sults showed that 5.7% of rhubarb treated women de-veloped PH, a rate substantially lower than the20.8% of the plaeebo group (P<0.01). After 9～10weeks of treatrnent, the plasma fibronectin (Fn) leveland Plaminogen activalor inhibiter (PAI) value werefound significantly lower (P<0.05) in the rhubarbtreated group than in the plaeebo. Antithrombin ill(ATIII) level also decreased significantly less in therhubarb group as conipared with the placebo(P< 0.05). It indicated that low dose of processed rhu-barb has a good prophylactic effect on PIH. Themechanism may be related with the inhibition of PAIactivity. reduced Fn syathesis and decreased damageto vascular endothelium.
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
1994年第8期463-464,共2页
Chinese Journal of Obstetrics and Gynecology
关键词
大黄
预防
妊娠高血压
综合征
Rhubarb Primary preventionPregnancy induced hypertension
