摘要
在大鼠主动脉球囊内膜剥脱术后血管壁细胞过度增殖模型上，用合成的血小板膜纤维蛋白原受体（ｇｌｙｃｏｐｒｏｔｅｉｎⅡｂ／Ⅲａｃｏｍｐｌｅｘ，ＧＰⅡｂ／Ⅲａ）拮抗剂ＲＧＤＳ（Ａｒｇ－Ｇｌｙ－Ａｓｐ－Ｓｅｒ，５０μｍｏｌ·ｋｇ－１·ｄ－１）治疗可有效地抑制损伤血管壁的细胞计数增加和内膜增厚以及血管平滑肌细胞增殖，显著降低其血管组织３Ｈ－ＴｄＲ和３Ｈ－Ｌｅｕ的参入增加程度。实验结果提示ＲＧＤＳ肽作为血管成型术的辅佐剂，对于防治血管再狭窄可能具有潜在的临床应用前景。
In the model of vascular wall cell proliferation induced by balloon catheter de-endothelialization in rat aorta, treatment with a synthetic Arg-Gly-Asp-Ser peptides (RGDS, a specific antagonist of platelet membrane glycoprotein Ⅱb/Ⅲa complex, 50 μmol·kg-1·d-1 for 3 days during days 1─3, days 8─10 and days 19─21 after de─endothelialization respectively) effectively inhibited the increase of cell count in the injured vessel wall, intimal thickening and 3H-TdR and 3H-leucine incorporation of vascular tissues. These results suggest that RGDS peptide, as an adjuvant of balloon angioplasty, may have potential significance in prevention and therapy of re-stenosis occurred in patients after angioplasty.
出处
《中国应用生理学杂志》
CAS
CSCD
1994年第3期229-233,共5页
Chinese Journal of Applied Physiology
关键词
RGDS肽
球囊剥脱术
主动脉模
增殖
balloon catheter de-endothelialization
RGDS peptide: vascular smooth muscle cell
platelet
GP Ⅱ_b/Ⅲ_a complex
