摘要
本实验研究了从Ｓｐｒａｇｕｅ－Ｄａｗｌｅｙ大鼠红细胞中提取的抗高血压因子（ａｎｔｉｈｙｐｅｒｔｅｎｓｉｖｅｆａｃｔｏｒ，ＡＨＦ）对苯肾上腺素引起的Ｗｉｓｔａｒ大鼠胸主动脉螺旋条预收缩的舒张作用。结果表明：ＡＨＦ对主动脉条的舒张呈内皮与剂量依赖性。左旋硝基精氨酸与美蓝均可阻断ＡＨＦ的舒血管作用，而铜锌超氧化物歧化酶对ＡＨＦ的舒血管效应有促进作用。提示ＡＨＦ是通过刺激内皮细胞产生一氧化氨或其类似物，从而激活血管平滑肌细胞内可溶性鸟苷酸环化酶这一途径引起血管舒张的。
The vasodilatory effects of antihypertensive factor(AHF) extracted from
erythrocytes ofmale Sprague-Dawley rats on aortic strips of Wistar rats were studied. The aortic
strips wereprecontracted with phenylephrine,and relaxation percentages caused by AHF at
several concen-trations were monitored. AHF relaxed the aortic strips in an endothelium-and
dose-dependentmanner.Such effects could be abolished by both NG-nitro-L-arginine and
methylene blue, andenhaneed by Cu-Zn superoxide dismutase. The results suggest that AHF
might stimulate releaseof EDRF (nitric oxide or a nitric oxide related compound)from endothelial
ceells. EDRF could inturn activate soluble guanylate cyclase in the underlying vascular
smooth muscle cells, leading tovasodilation.
出处
《中国应用生理学杂志》
CAS
CSCD
1994年第1期5-8,共4页
Chinese Journal of Applied Physiology
关键词
红细胞
抗高血压因子
内皮依赖性
rat
erythrocyte antihypertensive factor,
endothelium dependency
endothelium-derivedre-laxing factor
nitric oxide
