摘要
30只家兔烫伤前和烫伤后静脉注射丁胺卡那霉素(10mg/kg)的药动学资料比较的结果表明,20~30%体表面积三度烫伤后1周、2周和3周家兔的丁胺卡那霉素血浓度均明显降低;药动学参数也均表现为:半衰期(T1/2)缩短、分布容积(V1和Vd)增加、清除率(CL)增加和曲线下面积(AUC)减少。
hirty rabbits were grven wirh amikacin(10mg/kg )intravenously before and after scald burns respectively. The phar-macokinetic data showed that amikacin serum levels lowered signifecaltly in all rabbits with a third degree 20-30%TBSAburn on the day of 1、2 and 3 week postscald; the pharmacokinetic parameters also altered:the half life shortened,the destri-bution volumes(Vi and Vd )expanded,the clearance increased and the area under curve reduced.The results demonstratedthat the change of amikacin pharmacokinetics was evident drring hypermetabolic phase following thermal injury.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
1994年第2期51-54,共4页
Chinese Journal of Hospital Pharmacy
关键词
丁胺卡那霉素
药物动力学
烧伤
amikacin,pharmacokinetics,scaid burn,hypermetabolic phase