摘要
目的介绍血管内皮细胞在肿瘤侵袭微生态系统中的作用及研究进展。方法系统复习肿瘤侵袭微生态系统研究的背景、组成要素、与肿瘤微环境的区别及血管内皮细胞对其影响的相关文献,并予以归纳总结。结果肿瘤侵袭微生态系统是指肿瘤侵袭过程的细胞群落与其栖息宿主环境所构成的一个自然的整体功能系统,属于细胞和分子水平的生态系统,它包括肿瘤细胞本身在内,具有生态系统的规律;而肿瘤的微环境则与肿瘤侵袭微生态系统不同,它是肿瘤细胞赖以生存的所有外界条件的总称,是一种结构体系,不包括肿瘤细胞本身,不具有生态系统的规律。肿瘤侵袭微生态系统组成要素包括肿瘤细胞群落和宿主细胞群落以及它们的栖息环境(基质成分),而血管内皮细胞群落是最主要的宿主细胞群落,其对肿瘤侵袭微生态系统的作用主要表现在肿瘤细胞群落和内皮细胞群落之间的营养联系上,这种营养联系形成了肿瘤微生态系统的物质循环,包括营养循环和细胞基质循环。肿瘤侵袭转移是肿瘤细胞群落和血管内皮细胞群落不断重建营养联系的结果。结论血管内皮细胞通过和肿瘤细胞之间的营养联系对肿瘤侵袭微生态系统进行调控,切断肿瘤细胞群落和血管内皮细胞群落之间的营养联系是肿瘤治疗的关键。
Objective To review the effect of endothelial cells in the tumoral invasion miroecosystem(TIMES) and the progress of recent research in this field. Methods The relative references of TIMES, including investigative background, main components, differences compared with the tumor microenvironment, and effect of endothelial cell are studied systematically. Results The TIMES is considered as a naturally integreted functional unit which is composed of cell communities and host environment during the process of tumoral cells invading, it is an ecosystem at both cellular and molecular level. Being different from TIMES, the term of tumoral microenvironment means the environment conditions for the existence of tumor cells, it is a kind of constructive system, not including tumor cell itself, and not possessing the regulation of ecosystem. The main elements of TIMES include tumor cell communities, host cell communities, and their enviroment(extracellular matrix), among them the endothelial cell communities are the most important host communities. The main effect of endothelial cells on the TIMES is the trophic links between tumor cell communities and endothelial communities, which froms a material cycle, including nutritional and matrix cycyles. The tumoral invasion and metastasis result from the continuous rebuilding of trophic links between tumor cell communities and endthelial cell communities.Conclusions The endothelial cell regulates TIMES by its trophic links with tumor cell communities. To block the links between tumor cell communities and endothelial cell communities might be the one of the key factors in tumoral treatment.
出处
《解剖学报》
CAS
CSCD
北大核心
2005年第3期330-332,共3页
Acta Anatomica Sinica
基金
福建省科技厅资助项目(01Z034)
