摘要
角膜移植手术失败的主要原因是T细胞介导的免疫排斥反应,T细胞的充分活化需要共刺激信号的协同作用。研究表明CD40-CD154信号在角膜移植排斥中具有重要意义,阻断该信号可延长移植物的存活。本文就其分子特性、免疫学功能进行了综述,重点探讨了阻断该信号抑制角膜移植排斥反应的效应和机制。
The leading cause of corneal graft failure'is T cell-mediated immune rejection. Costimula-tion has been shown to be necessary for full activation of naive T cell. The interaction of CD40-CD154 plays important roles in corneal allograft rejection, and blockade of which has been demonstrated to result in prevention of allograft rejection. In this article, the molecule characters and immune function of CD40-CD154 costimulatory signal were reviewed, and the effects and mechanisms of blockade of this pathway on survival of allogeneic corneal transplantation were mainly discussed.
出处
《眼科新进展》
CAS
2005年第3期289-291,共3页
Recent Advances in Ophthalmology
