摘要
SD雌大鼠从妊娠d 16到分娩后d 21摄取含铅水,断奶后仔鼠仍摄取至出生后d 30,测试仔鼠行为。步下法中,第二次下台潜伏期缩短,5 min内的下台次数增加;水迷宫测试中,通过水迷宫的时间延长,进入盲端的次数增加;且自发活动增强,对新环境的适应性下降。结果表明低剂量铅使幼鼠学习和记忆能力下降,活动增加。
Dam rats were given Pb (0. 58. 1. 70. and 5. 27 mmol·L-1), containing water ad lib from d 16 of gestation to weaning of the offspring on d 21 postpartum. The pups continued drinking the same water till the postnatal d 30. The neurohehavioral function of pups was tested. The second step-down latencies ( SDL2 ) were shortened and the number of step-downs in 5 min (NSD) were increased in step-down test. The prolongation of the lapse of time in passing through the whole course (LTPWC) and the increase in number of entries into the blind alley (NEBA) were measured in water maze test. The number of ambulations and rearings were increased in locomotor activity. The results indicated that Pb exerts adverse effects on the learning ability and memory function , and induces hyperactivity in young rats.
出处
《中国药理学报》
CSCD
1994年第4期316-319,共4页
Acta Pharmacologica Sinica
基金
Ministry of Public Health. China,№ 0775203.
关键词
铅中毒
学习障碍
记忆障碍
lead poisoning
animal behav- ior
learning disorders
memory disorders
locomotion
