摘要
本文研究了汉防己甲素（ＴＥＴ）对犬缺氧性肺动脉高压时肺循环血流动力学及血气的影响。在急性肺泡缺氧犬模型，静脉注射ＴＥＴ使缺氧引起的肺动脉高压恢复４２％，但对Ｐｓａ无显著性影响，ＴＥＴ仪由缺氧引起下降的ＣＯ及升高的ＴＰＶＲ和ＳＶＲ恢复到接近呼吸室内空气时的水平。ＴＥＴ对动脉血无分压（ＰａＯ２）和血氧饱和度（ＳａＯ２）无形响，但由于其使ＣＯ升高，故明显增大氧搬运系数（ＴＯ２）．直线回归分析在明：ＴＥＴ降低肺动脉高压的作用与缺氧时肺动脉压升高的水平密切相关。我们的结论是：在缺氧性肺动脉高压犬，ＴＥＴ能明显降低升高的肺动脉压和肺血管阻力，并能提高心输出量和氧搬运能力，而对系统循环和血气水平无明显影响。
e studied t he effects of tetrandirine(TET)on pulmonary haemodynamics and blood gas changeduring hypoxic pulmonary hypertension. In the canine model of acute alveolar hypoxia,intravenous ad-ministration(iv)of tetrandrine(7.5mg/kg)restored 42%of increased Ppa produced by hypoxia,yet didnot significantly change Psa,Tetrandrine significantly restored CO,as well as TPVR and SVR chanhedby hypoxia.TET administration did not significantly change PaO2 and SaO2,yet it signififcantly in-creased Oxygen transport(TO2)because of marked increase of CO.Regression analysis showed that theeffect of TET against pulmonary hypertension is closely related to the increased level of Ppa by hypoxi-a. We concluded that tetrandrine has selectivity on acute hypoxic pulmonary hypertension and may beclinically useful for the treatment of patients with pulmonary hypertension.
出处
《中国医科大学学报》
CSCD
1994年第4期299-302,共4页
Journal of China Medical University
基金
国家自然科学基金
关键词
汉防己甲素
缺氧性
肺动肺高压
血流动力学
tetrandrine
hypoxic pulmonary hypertension
haemodynamics
blood gas
