摘要
目的:采用经颅磁刺激技术(TMS)探讨症状性运动部位相关癫患者发作间期运动皮质的兴奋性。方法:对诊断明确的34例癫患者(分治疗组和未治疗组)及20例年龄、性别匹配的正常对照组进行单脉冲经颅磁刺激,刺激部位头颅相应的运动手区和颈7棘突外侧,并于对侧小指外展肌记录运动诱发电位(MEP),分析其阈强度(TI)、周围潜伏期(PL)及皮质潜伏期(CL)、中枢传导时间(CCT)和静息期(SP)。结果:所有癫患者PL、CL及CCT均在正常范围内,但TI和SP明显低于正常对照组(P< 0.01)。在癫患者中,未治疗组TI及SP明显低于治疗组(P< 0.01),致灶侧TI及SP低于非致灶侧(P< 0.05),但非致灶侧SP亦缩短。结论:单脉冲低频TMS能有效地反映中枢运动皮质的功能状态,用于症状性运动部位相关癫患者发作间期运动皮质兴奋性研究具有重要的实用价值。
Objective:To assess whether single-pulse transcranial magnetic stimulation (TMS) can measure the interictal brain excitability of patients with symptomatic localization-related epilepsy (SLE). Methods:Thirty-four patients with SLE to be selected (including a team with treatment and another team without treatment), and 20 age-and-sexmatched healthy individuals were both performed by transcr anial magrertic stimulation to cortical area of hand and recording of motor eveked potential from contralateral abductor digiti minimi. The threshold intensity (TI), the duration of the cortical silent period (SP), cortical latency(CL), and central conduction time(CCT) of MEP in contralateral abductor digiti minimi were recorded and analysed. Results:CL and CCT were normal, but TI and SP were significantly lower in the patients than in the controls ( P < 0.01). Of 34 patients, 13 were untreated and 21 took one or more antiepileptic drugs. The untreated patients had a significantly lower TI and shorter SP than the treated patients ( P < 0.01). The hemisphere of epileptogenic area had a significantly lower TI and SP than the contralateral hemisphere ( P < 0.05), but the SP was also shortened on contralateral hemisphere .Conclusions:Single-pulse TMS is able to provide a valuable electrophysiologic insight into the interictal excitatory state of the cortex in the patients with SLE. The technical method can potentially supply useful clinical information.
出处
《临床神经电生理学杂志》
2005年第2期71-74,共4页
Journal of Clinical Electroneurophysiology
