摘要
目的:探讨CD44v6和MMP-2在食管癌组织中的表达及其与食管癌侵袭转移和预后的关系.方法:回顾性分析43例术前未进行化疗和放疗的食管癌的切除标本,采用免疫组化S-P法检测食管癌组织中的CD44v6和MMP-2的表达.结果:食管癌中CD44v6的阳性表达率62.7%(27/43),MMP-2的阳性表达率为65.1%(28/43),CD44v6及MMP-2的阳性表达与淋巴结的转移,食管癌的病理分以及手术后血性转移显著相关(P<0.05),而且,CD44v6阳性表达者3a生存率为25.62%,5a生存率为6.41%,阴性表达3a生存率为64.71%,5a生存率为56.82%,二者之间差异显著(P=0.000);MMP-2阳性者3a生存率为18.8%,5a生存率为8.67%,阴性表达者3a生存率为66.30%,5a生存率为42.66%,二者之间差异显著(P=0.0067);CD44v6的阳性表达和MMP-2的阳性表达显著性相关(P=0.007).结论:CD44v6和MMP-2对于食管鳞癌的侵袭、淋巴结转移、手术后血性转移以及预后有一定作用.
AIM: To detect the expression of CD44v6 and MMP-2 in esophagus squamous cell carcinoma, and to explore their association with invasion, metastasis and prognosis. METHODS: A rapid immunohistochemical method (streptoavidin-peroxidase,SP) was used to detect CD44v6 and MMP-2 protein in 43 cases of esophagus squamous cell carcinoma-treated without radiotherapy or chemotherapy before operation. RESULTS: The expression rates of CD44v6 and MMP-2 in esophagus squamous cell carcinoma were 62.7% (27/43) and 65.1% (28/43), respectively. The positive expression of MMP-2 and CD44v6 were significantly correlated with lymph node metastasis, TNM stage and postoperative hematogenous metastasis (P<0.05). The 3-and 5-year survival rates of CD44v6 positive patients were 25.62% and 6.41%. The 3-and 5-year survival rates of CD44v6 negative patients were 64.71% and 56.82%. There was significant difference for survival time between CD44v6 positive and CD44v6 negative patients (P=0.000). The 3-and 5-year survival rates of MMP-2 positive patients were 18.8% and 8.60%. The 3-and 5-year survival rates of MMP-2 negative patients were 66.30% and 42.82%. There was significant difference between MMP-2 positive and MMP-2 negative groups (P = 0.0067). CD44v6 positive expression was significantly correlated with MMP-2 positive expression (P= 0.007). CONCLUSION: CD44v6 and MMP-2 may play a role in esophagus squamous cell carcinoma invasion, lympha node metastasis, and postoperative hematogenous metastasis as well as the prognosis of the patients.
出处
《世界华人消化杂志》
CAS
北大核心
2005年第9期1074-1077,共4页
World Chinese Journal of Digestology
