摘要
奥曲肽（ＳＭＳ）治疗２．２±０．３年的９例肢端肥大症患者停药一周时的ＳＭＳ药代动力学结果为４例患者试验时仍有ＳＭＳ导致的胆囊收缩功能抑制及胆囊结石形成，另５例胆囊收缩功能已恢复正常。皮下注射ＳＭＳ１００μｇ后取血至１２ｈ，ＳＭＳ浓度时间曲线呈一室模型，ＳＭＳ吸收很快，［ｔ１／２（ａｂｓ）］为７．７±１．２ｍｉｎ，［ｃｐ（ｍａｘ）］于３０．９±４．１ｍｉｎ到达３．３±０．４μｇ／Ｌ，［ｔ１／２（ｅ）］为１１３．４±１３．５ｍｉｎ，［Ｋｅ］为０．００７±０．０１ｍｉｎ，［Ｖｄ］为３７．２±６．６Ｌ，［ＣＬＴ］为２５１．９±４９．０ｍｌ／ｍｉｎ。结果显示ＳＭＳ治疗引起的胆汁排泄延缓及胆囊收缩功能降低并未影响ＳＭＳ的药代动力学。
patients with acromegalia among them 4 with concurrent decreased gallbladder contraction and gallstone, the rest with normal gallbladder function,had been treated with octreotide for 2.2±0.3 years. The drug was discontinued for 72 hours before the commencement of this studv. Then octreotide was injected subcutaneously and blood samples were drawn at regular intervals up to 12 hours. Octreotide was rapidly absorbed with a[t1/2 (abs)] of 7.7±1.2 minutes. The [cp (tmax)] was reached in30.9±4.1 minutes to 3.3±0. 4I1g/L. The serum disposition showed a monoexponentialbehavior with a[t1/2(e)] of 113. 4±3. 5minutes and rate constant [Ke] of 0.007±0.01minutes. The[Vd] was 37.2±6.6 L and [CLT] was 251. 9±49.0ml/min.There was no significant difference in the pharmacokinetics between patients with dif-ferent conditions.
出处
《中国新药杂志》
CAS
CSCD
1994年第2期45-48,共4页
Chinese Journal of New Drugs
