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血小板源性生长因子mRNA水平在冠状动脉侧支循环形成中的作用 被引量:1

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摘要 目的:探讨血单核细胞血小板源性生长因子(PDGF)mRNA在冠状动脉侧支循环形成中的作用。方法:将行选择性冠状动脉造影术的34例患者分为非冠心病(CHD)组,5例;CHD组,29例(其中有侧支循环者8例,无侧支循环者21例)。通过RTPCR检测所有受试者主动脉根部及股动脉血单核细胞PDGFmRNA水平。结果:CHD患者无论是主动脉根部还是股动脉血单核细胞PDGFmRNA水平均较非CHD患者显著增加(P<0.01),CHD有侧支循环患者的主动脉根部血单核细胞PDGFmRNA水平较无侧支循环患者显著上升(P<0.01),但两者的股动脉血单核细胞PDGFmRNA水平变化无差异(P>0.05)。结论:PDGFmRNA水平与CHD密切相关,CHD侧支循环形成与否主要取决于冠状动脉局部单核细胞PDGFmRNA水平。
出处 《临床心血管病杂志》 CAS CSCD 北大核心 2005年第5期309-310,共2页 Journal of Clinical Cardiology
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