摘要
目的:分析ER、PR在垂体腺瘤中的表达,探讨ER、PR与垂体腺瘤侵袭性之间的关系。方法:取经手术切除且病理诊断为垂体腺瘤、具有完整内分泌资料的患者50例,根据Hardy-Wilson及Knosp分级、分期标准,结合病理活检判断其肿瘤侵袭性,用免疫组化方法分别检测每例肿瘤ER、PR的表达水平。结果:50例病人中ER、PR表达的阳性率分别为60.0%(30/50)和62.0%(31/50);ER表达水平与垂体腺瘤侵袭性之间存在负相关关系(r=-0.400,P<0.01),PR表达水平与垂体腺瘤侵袭性之间相关关系不显著(r=-0.215,P>0.05)。结论:ER的表达水平与垂体腺瘤侵袭性有关,其表达水平有可能作为判断垂体腺瘤侵袭性和预后的指标。
Objective To explore the expression of estrogen receptor (ER) and progesterone receptor (PR) in pituitary adenoma, and analysis study their correl ation with the invasiveness of the tumors. Methods Fifty patients were collected after surgery from patients after full endocrine preoperative evaluation. All t umors were graded and staged according to Hardy Wilson and Knosp classification , using magnetic resonance scanning. Immunohistochemical staining was adapted to semi quantify the expression of ER and PR. Results The prevalence of ER and PR were 60.0%and 62.0%in pituitary adenoma respectively. Significant negative co rrelation could be seen between the expression of ER and the invasiveness of pit uitary adenoma, but there was no clear relationship could be found between the e xpression of PR and the invasiveness of pituitary adenoma. Conclusion The expres sion of ER may be take as the markers to indicate invasiveness and prognosis of pituitary adenoma.
出处
《实用医学杂志》
CAS
2005年第10期1027-1029,共3页
The Journal of Practical Medicine
