摘要
目的了解异尖线虫Ⅲ期幼虫(L3)生物学特性及致病性。方法观察异尖线虫L3在不同的溶液、温度下的生存时间及感染大鼠后引起的病理变化。结果L3在-20℃10h后被杀死,在4-10℃能生存8个月以上。37℃时幼虫非常活跃,40℃以上可在短时间内死亡。腌制鱼生的配料不能杀死虫体。异尖线虫L3感染大鼠试验证实:约15%-25%的L32d内可能钻入消化道壁或腹腔,3d后不再构成危险,7-10d自行死亡,不能发育为成虫。动物空腹时易感染。病理学研究显示,初次感染以异物反应为特征,再次感染以过敏反应为特征。结论异尖线虫L3对外界环境有较强抵抗力,感染陆地哺乳动物后能在体内移行,但不能继续发育。
Objective To observe the characteristics of biology and pathogenicity of the third stage Anisakis simplex larvae ( L3). Methods The survival time of the L3 in various conditions was observed and the pathological change after experimental infection in rats was examined. Results The results showed that the L3 frozen at -20℃ for 10 - 12 h can be killed. In the temperature range of 4 - 10 ℃ , the L3 can survive for over 8 months. The L3 was very active at 37℃ , and was killed at the high temperature over 40℃ in a very short time. The ingredients for sashimi cannot kill the L3. The experiment of rats infected by the L, showed that about 15% -25% of the L3 penetrated into the gastrointestinal wall or migrated into the peritoneal cavity in 2 days. After 3d the L4 was not infectious, and died automatically in 7 - 10 days and could not develop into adults. The animals can be easily infected when the stomach was empty. The pathological study showed that the primary infection was a kind of reaction to foreign body, while that of the re - infection was allergic. Conclusion The L3 has a strong resistance to low temperature and to ingredients , it can be killed by freezing at -20℃ in 24 hours. The L3 can not mature in the body of terrestrial mammals but causes pathological change in the stomach and allergy.[
出处
《中国寄生虫学与寄生虫病杂志》
CAS
CSCD
北大核心
2005年第2期106-109,共4页
Chinese Journal of Parasitology and Parasitic Diseases
