摘要
目的:研究定志小丸的组方规律,探索其组成药物(人参、远志、石菖蒲、茯苓)之间的最佳用量配伍比例。方法:采用正交试验设计对方中组成药物进行药味及药量的加减拆方,检测各方对小鼠学习记忆能力和脑内乙酰胆碱酯酶(AchE)活力的影响。结果:试验表明,全方的益智作用大于其它方。人参益智作用最强,其余依次为远志、石菖蒲、茯苓。方中各药的最佳用量配伍比例为3∶2∶0 6∶3。结论:定志小丸全方的益智作用最强,方中四味药物的最佳用量配伍比例与原方基本一致,表明定志小丸的用量配比较为合理。
Objective:To study the formula of Dingzhi Xiaowan,and discuss the best proportion of four chinese medicines which compose it.Methods:Detect the ability of learning,memory and the energy of acetylcholine esterase (AchE) of the mice which were treated with different solutions prepared according to the orthogonal layout.Results & Conclusion:The effects of the formula composed of all four chinese medicines are better than others.Among the four Chinese medicines,Radix Ginseng presented the most significant effects on improving the ability of learning and memory in model mice,whereas Radix Polygalae,Rhizoma Acori Tatarinowii and Poria exhibited the attenuated properties in turn.This study showed that the best proportion of four Chinese medicines should be 3∶2∶0.6∶3 and indicated that the traditional proportion was reasonable.
出处
《中国实验方剂学杂志》
CAS
2005年第3期8-11,共4页
Chinese Journal of Experimental Traditional Medical Formulae
基金
江苏省科学技术厅社会发展基金项目(NO.BS2000090)
关键词
定志小丸
正交试验
用量配比
跳台法
乙酰胆碱酯酶
益智作用
Dingzhi Xiaowan
Orthogonal Experiments
Proportion
Step-down Test
Acetylcholine Esterase
Improve the Ability of Learning and Memory
