摘要
目的:评估UV吸收光谱在复方丹参片(滴丸)的鉴别和质量控制中的价值。方法:利用紫外分光光度计扫描不同厂家的复方丹参片、滴丸,以及其他不同品种中成药的UV吸收光谱(以水为溶剂)。对药物的UV吸收光谱进行相关分析,得到各产品之间的相互关系表,并依据表中的Pearson相关系数(R)和ΔR(PearsonsR与它的镜像位置值的绝对差值)对光谱的相似性进行比较。结果:相同厂家不同批号产品之间的UV吸收光谱的R=0.997～0.9999,光谱相似性极高;而不同厂家产品之间的R=0.92～0.997,ΔR<0.02,光谱相似性较高;与复方丹参片(滴丸)的UV吸收光谱相比,其他中成药光谱的R=0.25～0.98,ΔR>0.02,光谱相似性低。结论:UV吸收光谱可以用于复方丹参片(滴丸)的鉴别和质量控制。
Objective: To evaluate the value of UV absorption spectrum for identification and quality control of compound Danshen tablets and pills. Method: UV absorption spectra of compound Danshen tablets and pills, and other drugs were scanned using ultraviolet spectrophotometer(water as the solvent). Pearsons correlation coefficients(Pearsons R ) were displayed in the correlations table obtained from SPSS correlate, and ΔR defined as the absolute value of the difference between Pearsons R and its mirror image in the table were used for measuring the spectral similarity between two drugs from different manufacturers. Result: Regarding compound Danshen tablets and pills, the spectral similarity between different batch drugs from same manufacturer was very high with Pearsons R =0.995-0.999 9, and the similarity between two manufacturers was high with Pearsons R =0.92-0.997 and ΔR <0.02. Compared with the spectra of compound Danshen tablets and pills, the spectral similarity of the other drugs was low with Pearsons R =0.25-0.98 and ΔR >0.02. Conclusion: The results showed that UV absorption spectrum could be suitable for identification and quality control of compound Danshen tablets and pills.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2005年第7期507-510,共4页
China Journal of Chinese Materia Medica
