摘要
目的 研究十四酸异丙酯分子凝胶并探讨其促进透皮吸收的性能。方法 用扫描电镜和光学显微镜研究十四酸异丙酯分子凝胶的微观形态,用黏度法研究其流变性和触变性,以雷公藤甲素为模型药物考察其促进透皮吸收性能。结果 十四酸异丙酯分子凝胶的微观结构是由Span60在十四酸异丙酯中聚集形成的棒状小微管相互联结而成的三维网络结构。它有较好的流变性和触变性。载有雷公藤甲素的十四酸异丙酯分子凝胶的单位面积累计透皮量与时间成良好的线性关系,其渗透符合零级动力学过程,其平均透皮速率为19 26ng·cm-2·h-1,是目前市售雷公藤甲素软膏的2.92倍。结论 十四酸异丙酯能被Span60凝胶化,载有雷公藤甲素的十四酸异丙酯分子凝胶的透皮性能优于市售雷公藤甲素软膏。
Aim To prepare of isopropyl myristate (IPM) molecular gels and investigate of its transdermal capability. Methods Microstructure of IPM gels was studied by scanning electron microscope (SEM) and optical microscope (OM). The rheology and thixotropy of IPM gels were investigated by viscosity. Triptolide was used as model drug to investigate its transdermal capability. Results The microstructure of IPM gels was a three-dimension network formed by the aggregation of Span 60 in IPM, which was rod-like tubular aggregate. It has good rheology and thixotropy. There was a good linear correlation between the accumulative permeated amount per unit area and the time for triptolide-loaded IPM gels. The permeation process agreed with zero order pharmacokinetics. The average permeability through rat skin for triptolide was 19.26 ng·cm^(-2)·h^(-1), which was 2.92 times of triptolide unguents obtained commercially available. Conclusion Isopropyl myristate molercular gel can be formed by span 60 assemblies. Transdermal capability drug-loaded IPM gels was better than that of triptolide unguents.
出处
《药学学报》
CAS
CSCD
北大核心
2005年第5期470-474,共5页
Acta Pharmaceutica Sinica
基金
国家自然科学基金资助项目(29974102)
关键词
十四酸异丙酯分子凝胶
流变性
触变性
透皮性能
isopropyl myristate molecular gels
rheology
thixotropy
percutaneous abilities
