摘要
目的 观察尼莫地平(NM)鼻腔给药对犬脑血流动力学的影响。方法 采用电磁流量计检测犬静注、鼻腔和口服给药后脑血流量(CBF)的改变,并应用MFLab功能学科实验软件进行监测和数据处理。结果 鼻腔、静注给药后CBF明显增加,而口服变异大。3种途径给药后CBF平均增长率分别为28. 0%, 26. 4%和8 .5%。鼻腔给药后起效稍慢于静注[ (5±4)minvs(2. 2±1. 2)min],但平均作用持续时间最长[ (25±17)min]。结论 鼻腔给药有望成为静注或口服NM的替代途径。
Aim To investigate the effect of nimodipine (NM) on cerebral blood flow (CBF) in dogs following intranasal administration. Methods NM solution was administered intranasally, intravenously (iv), and orally to dogs and the change of CBF was determined by using electromagnetic blood flowmeter. MFLab experimental program was applied to monitor the experimental process and analyze data. Results CBF markedly increased after iv and intranasal application, while large variance was observed after oral dosing. CBF in dogs after three administrations increased by 26.4%, 28.0% and 8.5%, respectively, compared with that of baseline. Following intranasal administration, the onset of action was slightly slower than that after iv injection [(5±4) min vs (2.2±1.2) min], however the duration of improvement was the longest [(25±17) min]. Conclusion Intranasal delivery for NM can be a promising alternative to parenteral or oral administration.
出处
《药学学报》
CAS
CSCD
北大核心
2005年第5期466-469,共4页
Acta Pharmaceutica Sinica
基金
NationalNaturalScienceFoundationofChina(30171112)
关键词
尼莫地平
鼻腔给药
脑血流
nimodipine
intranasal administration
cerebral blood flow
