摘要
目的 研究芫花根次生代谢产物的化学组成。方法 芫花根以95%乙醇于60-70℃提取7d。提取物以硅胶、SephadexLH-20及HPLC等方法加以分离。分离产物以1D和2DNMR,MS,UV,IR及CD鉴定其结构。结果从芫花根醇提物中分离出3个双黄酮,其结构被鉴定为毛瑞香素H-3 甲醚(1)、毛瑞香素H 3″甲醚(2)和毛瑞香素G-3″甲醚(3)。结论 化合物1,2和3为新的双黄酮类化合物。
Aim To investigate the chemical constituents of the secondary metabolites of the roots of Daphne genkwa. Methods The roots of D.genkwa were extracted with 95% ethanol at 60-70 ℃ for 7 days to obtain the crude extract. The crude extract was purified by silica gel and Sephadex LH-20 column chromatography as well as the HPLC techniques. The structures of the isolates were elucidated by combined spectroscopic methods including 1D and 2D NMR, MS, UV, IR and CD. Results Three new biflavonoids were isolated from the ethanol extract of the roots of D.genkwa and their structures were identified as daphnodorin H-3-methyl ether (1), daphnodorin H-3″-methyl ether (2) and daphnodorin (G-3″-methyl) ether (3). Conclusion Compounds 1, 2 and 3 are three new biflavonoids.
出处
《药学学报》
CAS
CSCD
北大核心
2005年第5期438-442,共5页
Acta Pharmaceutica Sinica
基金
NaturalScienceFoundationofNationalEducationMinistry ( 03049 )
KeyProgramofNaturalScienceFoundationofEducationDepartmentofJiangsuProvince( 02KJA360002 )
CooperativeJointResearchFoundationsoftheKeyLabforBiotechnologyonMedicinalPlantsofJiangsuProvince(KJS02114)
关键词
芫花根
双黄酮类化合物
瑞香科
roots of Daphne genkwa
biflavonoids
Thymelaeaceae
