摘要
β3-肾上腺素受体可调节人体热量平衡、葡萄糖代谢、能量消耗并纠正产热不足,可用于治疗肥胖症和2型糖尿病。选择性b3-肾上腺素受体激动剂主要有芳基乙醇胺和芳氧基丙醇胺两类,本文对这些化合物的研究进展进行了综述。
The b3-adrenoceptor plays a role in energy balance and glucose homeostasis. b3-Adrenoceptor agonisthas promising potential to be a therapeutic agent in the treatment of obesity and type 2 diabetes. Selective b3-adrenoceptoragonists fall into two main chemical classes, arylethanolamines and aryloxypropanolamines. This review is focused on theprogress of research and development of these compounds as antiobesity drugs.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2005年第3期180-184,共5页
Chinese Journal of Pharmaceuticals
