摘要
静脉注射ＢａＩｂ／ｃ小鼠（Ｈ－２￣ｄ）脾细胞和骨髓细胞，４８小时后，腹腔注射环磷酰胺和抗胸腺细胞血清，可诱导Ｂ６小鼠（Ｈ－２￣ｂ）对ＢａＩｂ／ｃ小鼠皮肤移植的长期耐受（＞８０天）．耐受Ｂ６小鼠可正常排斥无关品系ＣＢＡ／Ｊ小鼠（Ｈ－２￣ｋ）的皮肤，显示了耐受的特异性。上述诱导方案可导致受体小鼠脾细胞对ＣｏｎＡ、ＬＰＳ诱导的增植反应的抑制，但这种全身性免疫抑制可在短期内恢复，而供体特异性的同种异型反应，如ＭＬＲ和ＤＴＨ则不能恢复。
When C57BL/6(B6)mice (H-2￣
b)received an intravenous injection of allogeneic spleen cellsand
bone marrow cells from Balb/c mice(H-2￣d),followed by an
intraperitoneal injection of cy-clophosphamide and antithymocyte
serum 48 hours Iater, a long-Iasting survival(>80 days)ofskin
allograft was achieved.The B6 mice made tolerant to Balb/c mice kept
the potency of re-jecting the skin graft from third party CBA/J
mice(H-2￣K),demonstrating the specifity of thetolerance. This
tolerance induction protocol would result in the non-specific
inhibition of ConAand LPS-induced Iymphocyte proliferations of spleen
cells in the tolerant mice. However,thisgeneral immunosuppression
could recover in a short period. In contrast,Donor-specific
allogeneicresponses,such as MLR and DTH,are completely abrogated.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
1994年第5期274-277,共4页
Chinese Journal of Immunology
