摘要
目的探讨低分子肝素对脑梗死后炎症反应的干预作用。方法应用ELISA方法测定低分子肝素组和葛根素组患者治疗前后TNF蛳α、IL蛳6、IL蛳16、sVCAM蛳1和D蛳Dimer水平。结果低分子肝素组、葛根素组患者TNF蛳α、IL蛳6、IL蛳16、sVCAM蛳1和D蛳Dimer含量明显高于正常对照组,低分子肝素组患者上述指标在治疗后明显下降,于治疗前比较有显著性差异(P<0.01)。结论炎症细胞因子确实参与了急性缺血后的炎症反应,低分子肝素能够抑制细胞因子的表达,可能成为预防急性缺血性梗死后早期病情恶化的有前途的治疗手段。
Objective To observe the inflammatory reactions after acute cerebral ischemia and to investigate the anti-inflammatory effect of low-molecular-weight heparin (Fraxiparine). Methods Serum TNF-α, IL-6, IL-16, sVCAM-1 and plasma D-Dimer concentrations were measured by ELISA method before and after treatment with Fraxiparine and Kakonein respectively. Results The concentrations of TNF-α, IL-6, IL-16, sVCAM-1 in serum and D-Dimer in plasma of all the patients suffered from acute cerebral infarction were higher than those of normal control. Their concentrations were much lower in Fraxiparine. The difference was statistically significant. Conclutions Inflammatory cytokines are indeed involved in inflammatory reactions in acute cerebral ischemia. The low-molecular-weight heparin, Fraxiparine, can inhibit the expression of cytokines, and can be a promising medication to prevent early deterioration in acute ischemic stroke.
出处
《北京医学》
CAS
2005年第4期198-200,共3页
Beijing Medical Journal
关键词
低分子肝素
脑梗死
炎症反应
干预作用
Low-molecular-weight heparin Cerebral ischemia Inflammation Reperfusion injury
