摘要
高血压病患者１５例，用吲哒帕胺２．５ｍｇ／ｄ；另１３例患者用尼群地平２０－３０ｍｇ／ｄ作为对照，两组疗程均为６个月。与治疗前比较，吲哒帕胺组左心室肌重量指数减轻２９ｇ／ｍ２（Ｐ＜０．０１），尼群地平组减轻２５ｇ／ｍ２（Ｐ＜０．０１），两组间比较无显著性差异。两组患者左心室收缩功能与大多数舒张功能指标于治疗前后未见明显变化。本文提示吲哒帕胺与尼群地平均能有效地减轻高血压病左心室肥厚。
Fifteen patients(M10,F5;age 57±6 year)with essential hypertension were treated with indapaminde 2.5 mg/d,another l3 patients received nitrendipine 20-30 mg/d to serve as control.Both drugs were taken 6 months as a course of therapy.The results by using echocardiography showed a reduction in left ventricular mass index in indapaminde group(from 138 g/m2 to 109 g/m2,P<0.001),but there is no statistical difference between groups.With regard to cardiac systemic function and most indices of diastolic function there were no appreciable changes in both groups.It is suggested that both indapaminde and nitrendipine are effective for decreasing of hypertensive ventricular hypertrophy
出处
《中国临床药理学杂志》
CSCD
北大核心
1994年第4期211-214,205,共5页
The Chinese Journal of Clinical Pharmacology
关键词
吲哒帕胺
高血压
心肌肥厚
药理学
尼群地平
indapaminde
(nitrendipine)
pharmacodynamics
hypertension
ventricula hypertroghy
