摘要
本文报道了国产酒石酸吉他霉素理化性质的研究。Ｘ－射线衍射分析证明，用喷雾干燥法制备的酒石酸吉他霉素为无定形。差示扫描量热法和热重分析表明，本品不含结晶水；在１０７～１１６℃融化；１９９℃以上时迅速分解。它在室温条件下有吸湿性其临界相对湿度为９５％。在水、甲醇、丁醇、丙酮中极易溶解，易溶于氯仿；微溶于醋酸乙酯；在乙醚、四氯化碳中极微溶解；不溶于苯、石油醚和乙烷。本品在水中的比旋度。３．０％水溶液的ｐＨ值为）１～４．３。对光稳定，而在高温或高湿条件下不稳定。
The physico-chomical properties of Kitasamycin tartrate(KT) made in China were studied. X-rays diffraction analysis showed that KT prepared with spray-drying process was amorphous,Differential scanning calorimetry and thermal gravimetric analysis showed that KTcontained no crystal water,melted at 107～116℃,and decomposed at 199℃。 KT absorbed moisture at room temperature,and its critical rela-tive humidity was 95%,KT was very soluble in water,methanol,eth-anol,or acetone;freely soluble in chloroform; slightly soluble in ethyl acetate,very slightly soluble in ether or carbon tetrachloride;insolub-le in benzene,petroleurm ether,or hexane.Its specific rotation in water was-39.6°～-42.8°,The pH value of its water solution of 3.0% was 4.1～4.3.KT was stable to light,but unstable to high telnperatureor high humidity.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
1994年第6期423-426,共4页
Chinese Journal of Antibiotics
关键词
酒石酸
吉他霉素
理化性质
Kitasamycin tartrate
Physico-chemical properties
