摘要
本文报道国产洛美沙星在正常志愿者中的药物动力学研究结果。８名正常志愿者单次空腹口服洛美沙星片剂４００ｍｇ后的体内过程符合二室模型，其吸收迅速，平均血药峰浓度为４．１３±１．２０ｍｇ／Ｌ，于给药后１．２６±１．０９ｈ到达，其消除半衰期（Ｔ１／β）为６，７８±０．８１ｈ。给药量的５９．９±７．３％和６７．０±６．６％分别于服药后２４ｈ和７２ｈ内自尿中排出，尿药峰浓度平均为３９１±１８７ｍｇ／Ｌ。正常志愿者单次空腹口服国产片剂及胶囊４００ｍｇ后的体内过程与进口胶囊相仿，主要药代参数亦相近，相对生物利用度相仿。正常志愿者单次空腹口服国产洛美沙星片剂１００～８００ｍｇ剂量后均能很好耐受。根据研究结果，对洛美沙星的给药方案提出建议。
The pharmacokinetics of domestic made Lomefloxacin in healthy volunteers was described,The experimental data obatined in 8 healthy volunters after a single dose of 400 mg Lomefloxacin tablets could be fitted to a two comoartment model,It was absorbed rapidly and the mean peak Serurrl drug concentration was 4.13± 1.20mg/Lat 1.26 0± 1.09 h after druan adminisration. Its elimination half-life(T1/2β)was 6.78± 0.81 h. 59.9±7.3%and 67.0 ± 6.6%of the given dosage were excreted in urine within 24 h and 72 h respectively,Mean peak urine drug concentration was 391 ± 187mg/L. The pharmracokinetic parameters and relative biloava-ilability of domestic made tablet and capsule after a single dose of 400 mg were similar with that of imported Capsule.It was well tolerated in nor-mal volunteers after a single dosc of100 to 800 mg. According to the res-ults In this paper,a scheme of dosage of Lomefloxacin was suggested.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
1994年第4期248-252,共5页
Chinese Journal of Antibiotics
